Epigenetic roles of MLL oncoproteins are dependent on NF-κB.
Ontology highlight
ABSTRACT:
SUBMITTER: Kuo HP
PROVIDER: S-EPMC3816582 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Publications
Epigenetic roles of MLL oncoproteins are dependent on NF-κB.
Kuo Hsu-Ping HP Wang Zhong Z Lee Dung-Fang DF Iwasaki Masayuki M Duque-Afonso Jesus J Wong Stephen H K SH Lin Chiou-Hong CH Figueroa Maria E ME Su Jie J Lemischka Ihor R IR Cleary Michael L ML
Cancer cell 20130919 4
MLL fusion proteins in leukemia induce aberrant transcriptional elongation and associated chromatin perturbations; however, the upstream signaling pathways and activators that recruit or retain MLL oncoproteins at initiated promoters are unknown. Through functional and comparative genomic studies, we identified an essential role for NF-κB signaling in MLL leukemia. Suppression of NF-κB led to robust antileukemia effects that phenocopied loss of functional MLL oncoprotein or associated epigenetic ...[more]
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