Clock gene expression in gravid uterus and extra-embryonic tissues during late gestation in the mouse.

ABSTRACT: Evidence in humans and rodents suggests the importance of circadian rhythmicity in parturition. A molecular clock underlies the generation of circadian rhythmicity. While this molecular clock has been identified in numerous tissues, the expression and regulation of clock genes in tissues relevant to parturition is largely undefined. Here, the expression and regulation of the clock genes Bmal1, Clock, cryptochrome (Cry1/2) and period (Per1/2) was examined in the murine gravid uterus, placenta and fetal membranes during late gestation. All clock genes examined were expressed in the tissues of interest throughout the last third of gestation. Upregulation of a subset of these clock genes was observed in each of these tissues in the final two days of gestation. Oscillating expression of mRNA fo

SUBMITTER: Ratajczak CK 

PROVIDER: S-EPMC3816753 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature