Association between TGF-β1 polymorphisms and hepatocellular carcinoma risk: a meta-analysis.

ABSTRACT:

Background

Associations between transforming growth factor (TGF)-β1 polymorphisms and hepatocellular carcinoma (HCC) risk remained controversial. Therefore, we performed this meta-analysis to investigate these associations.

Methods

We searched Pubmed, EMBASE, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases for studies before March 2013. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association.

Results

A total of 14 studies were included in this meta-analysis. TGF-β1 +869C/T polymorphism was significantly associated with HCC risk (OR=1.74, 95% CI: 1.22-2.47, p=0.002). In addition, a significant association between -509C/T polymorphism and HCC risk was observed (OR=1.40, 95% CI: 1.15-1.70, p=0.0007)

SUBMITTER: Guo Y 

PROVIDER: S-EPMC3816781 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature