Screening biomarkers of prostate cancer by integrating microRNA and mRNA microarrays.

ABSTRACT:

Objective

In this study, we screened microRNA (miRNA) target genes of prostate cancer by integrating miRNA and mRNA expression profiles after target prediction and performed function enrichment analysis for selected candidate genes.

Methods

The miRNA expression profile (GSE36802) and mRNA expression profile (GSE36801) were downloaded from the Gene Expression Omnibus database. We processed data and identified the differentially expressed miRNAs and mRNAs with R packages. Verified targets of miRNAs were identified through miRecods and miRTarBase. Then, software of Search Tool for the Retrieval of Interacting Genes was used to construct the interaction network of target genes. Finally, we performed function enrichment analysis for genes in the interaction network with the Funct

SUBMITTER: Feng J 

PROVIDER: S-EPMC3816787 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature