Long-lasting improvements in liver fat and metabolism despite body weight regain after dietary weight loss.

ABSTRACT:

Objective

Weight loss reduces abdominal and intrahepatic fat, thereby improving metabolic and cardiovascular risk. Yet, many patients regain weight after successful diet-induced weight loss. Long-term changes in abdominal and liver fat, along with liver test results and insulin resistance, are not known.

Research design and methods

We analyzed 50 overweight to obese subjects (46 ± 9 years of age; BMI, 32.5 ± 3.3 kg/m2; women, 77%) who had participated in a 6-month hypocaloric diet and were randomized to either reduced carbohydrates or reduced fat content. Before, directly after diet, and at an average of 24 (range, 17-36) months follow-up, we assessed body fat distribution by magnetic resonance imaging and markers of liver function and insulin resistance.

Results

Body

SUBMITTER: Haufe S 

PROVIDER: S-EPMC3816862 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature