Needle-free jet injection of rapid-acting insulin improves early postprandial glucose control in patients with diabetes.

ABSTRACT:

Objective

Clamp studies have shown that the absorption and action of rapid-acting insulin are faster with injection by a jet injector than with administration by conventional pen. To determine whether these pharmacokinetic changes also exist in patients with diabetes and benefit postprandial glucose control, we compared the pharmacologic profiles of insulin administration by jet injection versus conventional insulin pen after a standardized meal in patients with type 1 or type 2 diabetes.

Research design and methods

In a randomized, double-blind, double-dummy crossover study, 12 patients with type 1 diabetes and 12 patients with type 2 diabetes received insulin aspart either by jet injection or by conventional pen, in both cases followed by a standardized meal. Blood was sam

SUBMITTER: Engwerda EE 

PROVIDER: S-EPMC3816925 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature