Dose-dense temozolomide for newly diagnosed glioblastoma: a randomized phase III clinical trial.

ABSTRACT:

Purpose

Radiotherapy with concomitant and adjuvant temozolomide is the standard of care for newly diagnosed glioblastoma (GBM). O(6)-methylguanine-DNA methyltransferase (MGMT) methylation status may be an important determinant of treatment response. Dose-dense (DD) temozolomide results in prolonged depletion of MGMT in blood mononuclear cells and possibly in tumor. This trial tested whether DD temozolomide improves overall survival (OS) or progression-free survival (PFS) in patients with newly diagnosed GBM.

Patients and methods

This phase III trial enrolled patients older than age 18 years with a Karnofsky performance score of ≥ 60 with adequate tissue. Stratification included clinical factors and tumor MGMT methylation status. Patients were randomly assigned to standard te

SUBMITTER: Gilbert MR 

PROVIDER: S-EPMC3816958 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature