Randomized trial to assess the impact of venlafaxine and soy protein on hot flashes and quality of life in men with prostate cancer.

ABSTRACT:

Purpose

Hot flashes occur in approximately 80% of androgen-deprived men. Few intervention studies have been conducted to relieve hot flashes in men.

Patients and methods

Eligible androgen-deprived men were randomly assigned to one of four daily regimens (2 × 2 factorial design) for 12 weeks: milk protein powder and placebo pill, venlafaxine and milk protein powder, soy protein powder and placebo pill, or venlafaxine and soy protein powder. The primary end point was hot flash symptom severity score (HFSSS), defined as number of hot flashes times severity. The secondary end point was quality of life (QoL), assessed by using the Functional Assessment of Cancer Therapy-Prostate.

Results

In all, 120 men age 46 to 91 years participated. Most were white (78%) and overweight

SUBMITTER: Vitolins MZ 

PROVIDER: S-EPMC3816959 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature