Translational Bioinformatics Approaches to Drug Development.

ABSTRACT:

Significance

A majority of therapeutic interventions occur late in the pathological process, when treatment outcome can be less predictable and effective, highlighting the need for new precise and preventive therapeutic development strategies that consider genomic and environmental context. Translational bioinformatics is well positioned to contribute to the many challenges inherent in bridging this gap between our current reactive methods of healthcare delivery and the intent of precision medicine, particularly in the areas of drug development, which forms the focus of this review.

Recent advances

A variety of powerful informatics methods for organizing and leveraging the vast wealth of available molecular measurements available for a broad range of disease contexts

SUBMITTER: Readhead B 

PROVIDER: S-EPMC3817001 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature