Variance heterogeneity in Saccharomyces cerevisiae expression data: trans-regulation and epistasis.

ABSTRACT: Here, we describe the results from the first variance heterogeneity Genome Wide Association Study (VGWAS) on yeast expression data. Using this forward genetics approach, we show that the genetic regulation of gene-expression in the budding yeast, Saccharomyces cerevisiae, includes mechanisms that can lead to variance heterogeneity in the expression between genotypes. Additionally, we performed a mean effect association study (GWAS). Comparing the mean and variance heterogeneity analyses, we find that the mean expression level is under genetic regulation from a larger absolute number of loci but that a higher proportion of the variance controlling loci were trans-regulated. Both mean and variance regulating loci cluster in regulatory hotspots that affect a large number of phenotypes; a sing

SUBMITTER: Nelson RM 

PROVIDER: S-EPMC3817098 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature