MiR-25 and miR-92a regulate insulin I biosynthesis in rats.

ABSTRACT: The 3' UTR of insulin has been identified as a critical region that confers mRNA stability, which is crucial for promoting transcription in response to glucose challenge. miRNAs are endogenously encoded non-coding RNAs that function as regulators of gene expression. This regulatory function is generally mediated by complementary binding to the 3'UTR of its mRNA targets that affects subsequent translational process. Genes involved in the regulation of glucose homeostasis, particularly in insulin production, have been found as targets of several miRNAs. Yet, no direct miRNA-based regulators of insulin biosynthesis have been identified. In this study, identification of possible miRNA-based regulators of insulin production is explored. Members of a miRNA family, miR-25 and miR-92a, are found a

SUBMITTER: Setyowati Karolina D 

PROVIDER: S-EPMC3817158 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature