Ontology highlight
ABSTRACT:
SUBMITTER: Lancaster MA
PROVIDER: S-EPMC3817409 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Nature 20130828 7467
The complexity of the human brain has made it difficult to study many brain disorders in model organisms, highlighting the need for an in vitro model of human brain development. Here we have developed a human pluripotent stem cell-derived three-dimensional organoid culture system, termed cerebral organoids, that develop various discrete, although interdependent, brain regions. These include a cerebral cortex containing progenitor populations that organize and produce mature cortical neuron subty ...[more]