Total synthesis of (-)-epimyrtine by a gold-catalyzed hydroamination approach.

ABSTRACT: A new approach to the total synthesis of (-)-epimyrtine has been developed from D-alanine. The key step to access the enantiopure pyridone intermediate was achieved by a gold-mediated cyclization. Finally, various transformations afforded the natural product in a few steps and good overall yield.

SUBMITTER: Trinh TT 

PROVIDER: S-EPMC3817515 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature