Statistical distributions of test statistics used for quantitative trait association mapping in structured populations.

ABSTRACT:

Background

Spurious associations between single nucleotide polymorphisms and phenotypes are a major issue in genome-wide association studies and have led to underestimation of type 1 error rate and overestimation of the number of quantitative trait loci found. Many authors have investigated the influence of population structure on the robustness of methods by simulation. This paper is aimed at developing further the algebraic formalization of power and type 1 error rate for some of the classical statistical methods used: simple regression, two approximate methods of mixed models involving the effect of a single nucleotide polymorphism (SNP) and a random polygenic effect (GRAMMAR and FASTA) and the transmission/disequilibrium test for quantitative traits and nuclear families. Analyt

SUBMITTER: Teyssedre S 

PROVIDER: S-EPMC3817592 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature