Variations in chromosomes 9 and 6p21.3 with risk of non-Hodgkin lymphoma.

ABSTRACT:

Background

There is growing evidence linking genetic variations to non-Hodgkin lymphoma (NHL) etiology. To complement ongoing agnostic approaches for identifying susceptibility genes, we evaluated 488 candidate gene regions and their relation to risk for NHL and NHL subtypes.

Methods

We genotyped 6,679 tag single nucleotide polymorphisms (SNPs) in 947 cases and 826 population-based controls from a multicenter U.S. case-control study. Gene-level summary of associations were obtained by computing the minimum P value ("minP test") on the basis of 10,000 permutations. We used logistic regression to evaluate the association between genotypes and haplotypes with NHL. For NHL subtypes, we conducted polytomous multivariate unconditional logistic regression (adjusted for sex, race, a

SUBMITTER: Wang SS 

PROVIDER: S-EPMC3817834 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature