Dietary sodium restriction and association with urinary marinobufagenin, blood pressure, and aortic stiffness.

ABSTRACT:

Background and objectives

Systolic BP and large elastic artery stiffness both increase with age and are reduced by dietary sodium restriction. Production of the natriuretic hormone marinobufagenin, an endogenous α1 Na+,K+-ATPase inhibitor, is increased in salt-sensitive hypertension and contributes to the rise in systolic BP during sodium loading.

Design, setting, participants, & measurements

The hypothesis was that dietary sodium restriction performed in middle-aged/older adults (eight men and three women; 60 ± 2 years) with moderately elevated systolic BP (139 ± 2/83 ± 2 mmHg) would reduce urinary marinobufagenin excretion as well as systolic BP and aortic pulse-wave velocity (randomized, placebo-controlled, and crossover design). This study also explored the associations

SUBMITTER: Jablonski KL 

PROVIDER: S-EPMC3817896 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature