Short-term changes after a weight reduction intervention in advanced diabetic nephropathy.

ABSTRACT:

Background and objectives

Obesity precedes and is strongly linked to the development of type 2 diabetic nephropathy in most patients, yet little is known about the effects of weight reduction on this disease. This study aimed to establish proof of concept for the hypothesis that weight reduction ameliorates diabetic nephropathy.

Design, setting, participants, & measurements

Six obese individuals with advanced diabetic nephropathy (estimated GFR <40 ml/min per 1.73 m(2), urine albumin excretion >30 mg/d) currently taking a renin-aldosterone axis inhibitor underwent a 12-week very low calorie ketogenic weight reduction diet with encouragement of exercise between March and September 2012. Albuminuria and other parameters of kidney health were the main outcome measures.

Resul

SUBMITTER: Friedman AN 

PROVIDER: S-EPMC3817909 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature