Carbamylation of serum albumin and erythropoietin resistance in end stage kidney disease.

ABSTRACT:

Background and objectives

The mechanisms underlying erythropoietin resistance are not fully understood. Carbamylation is a post-translational protein modification that can alter the function of proteins, such as erythropoietin. The hypothesis of this study is that carbamylation burden is independently associated with erythropoietin resistance.

Design, setting, participants, & measurements

In a nonconcurrent prospective cohort study of incident hemodialysis patients in the United States, carbamylated albumin, a surrogate of overall carbamylation burden, in 158 individuals at day 90 of dialysis initiation and erythropoietin resistance index (defined as average weekly erythropoietin dose [U] per kg body weight per hemoglobin [g/dl]) over the subsequent 90 days were measured. Li

SUBMITTER: Kalim S 

PROVIDER: S-EPMC3817911 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature