Targeted maximum likelihood estimation in safety analysis.

ABSTRACT:

Objectives

To compare the performance of a targeted maximum likelihood estimator (TMLE) and a collaborative TMLE (CTMLE) to other estimators in a drug safety analysis, including a regression-based estimator, propensity score (PS)-based estimators, and an alternate doubly robust (DR) estimator in a real example and simulations.

Study design and setting

The real data set is a subset of observational data from Kaiser Permanente Northern California formatted for use in active drug safety surveillance. Both the real and simulated data sets include potential confounders, a treatment variable indicating use of one of two antidiabetic treatments and an outcome variable indicating occurrence of an acute myocardial infarction (AMI).

Results

In the real data example, there is no

SUBMITTER: Lendle SD 

PROVIDER: S-EPMC3818128 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature