Severe painful vaso-occlusive crises and mortality in a contemporary adult sickle cell anemia cohort study.

ABSTRACT:

Background

Frequent painful vaso-occlusive crises (VOCs) were associated with mortality in the Cooperative Study of Sickle Cell Disease (CSSCD) over twenty years ago. Modern therapies for sickle cell anemia (SCA) like hydroxyurea are believed to have improved overall patient survival. The current study sought to determine the relevance of the association between more frequent VOCs and death and its relative impact upon overall mortality compared to other known risk factors in a contemporary adult SCA cohort.

Methods

Two hundred sixty four SCA adults were assigned into two groups based on patient reported outcomes for emergency department (ED) visits or hospitalizations for painful VOC treatment during the 12 months prior to evaluation.

Results

Higher baseline hematocr

SUBMITTER: Darbari DS 

PROVIDER: S-EPMC3818240 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature