Relationship between air pollution and positivity of RA-related autoantibodies in individuals without established RA: a report on SERA.

ABSTRACT:

Introduction

Studies suggest that respiratory exposures including smoking, proximity to traffic and air pollution might be associated with development of rheumatoid arthritis (RA). RA-related autoantibodies are predictive of the development of RA.

Objective

We evaluated the relationship between RA-related autoantibodies and exposure to particulate matter (PM), a measure of air pollution of interest to health, in individuals without RA.

Methods

The Studies of the Etiology of Rheumatoid Arthritis (SERA) is a multicentre study following first-degree relatives (FDRs) of a proband with RA. FDRs are without the 1987 ACR (American College of Rheumatology) classifiable RA at enrolment and are followed for the development of RA-related autoimmunity. RA-related autoantibody out

SUBMITTER: Gan RW 

PROVIDER: S-EPMC3818364 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature