Molecular Pathways: Targeting MYC-induced metabolic reprogramming and oncogenic stress in cancer.

ABSTRACT: MYC is a multifunctional transcription factor that is deregulated in many human cancers. MYC impacts a collaborative genetic program that orchestrates cell proliferation, metabolism, and stress responses. Although the progression of MYC-amplified tumors shows robust dependence on MYC activity, directly targeting MYC as a therapeutic method has proven to be technically difficult. Therefore, alternative approaches are currently under development with a focus on interference with MYC-mediated downstream effects. To fuel rapid cell growth, MYC reprograms cancer cell metabolism in a way that is substantially different from normal cells. The MYC-induced metabolic signature is characterized by enhanced glucose and glutamine uptake, increased lactate production, and altered amino acid metabolism.

SUBMITTER: Li B 

PROVIDER: S-EPMC3818456 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature