Maternal Western-style high fat diet induces sex-specific physiological and molecular changes in two-week-old mouse offspring.

ABSTRACT: Maternal diet is associated with the development of metabolism-related and other non-communicable diseases in offspring. Underlying mechanisms, functional profiles, and molecular markers are only starting to be revealed. Here, we explored the physiological and molecular impact of maternal Western-style diet on the liver of male and female offspring. C57BL/6 dams were exposed to either a low fat/low cholesterol diet (LFD) or a Western-style high fat/high cholesterol diet (WSD) for six weeks before mating, as well as during gestation and lactation. Dams and offspring were sacrificed at postnatal day 14, and body, liver, and blood parameters were assessed. The impact of maternal WSD on the pups' liver gene expression was characterised by whole-transcriptome microarray analysis. Exclusively ma

SUBMITTER: Mischke M 

PROVIDER: S-EPMC3818485 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature