Impact of treatment exposures on cardiovascular risk and insulin resistance in childhood cancer survivors.

ABSTRACT:

Background

Childhood cancer survivors (CCS) are more insulin resistant and have higher levels of several cardiovascular risk factors even while still children. This study examines specific treatment exposures associated with cardiovascular risk factors and insulin resistance.

Methods

CCS of ages 9 to 18 years at study entry and in remission 5 years or more from diagnosis (n = 319) and 208 sibling controls were recruited into this cross-sectional study that included physiologic assessment of insulin resistance (hyperinsulinemic euglycemic clamp) and assessment of cardiovascular risk factors. Regression and recursive tree modeling were used to ascertain treatment combinations associated with insulin resistance and cardiovascular risk.

Results

Mean current age of CCS was

SUBMITTER: Baker KS 

PROVIDER: S-EPMC3818503 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature