Ontology highlight
ABSTRACT:
SUBMITTER: Medema MH
PROVIDER: S-EPMC3818869 | biostudies-literature | 2011 Mar
REPOSITORIES: biostudies-literature
Microbial biotechnology 20101102 2
To increase production of the important pharmaceutical compound clavulanic acid, a β-lactamase inhibitor, both random mutagenesis approaches and rational engineering of Streptomyces clavuligerus strains have been extensively applied. Here, for the first time, we compared genome-wide gene expression of an industrial S. clavuligerus strain, obtained through iterative mutagenesis, with that of the wild-type strain. Intriguingly, we found that the majority of the changes contributed not to a complex ...[more]