Ontology highlight
ABSTRACT:
SUBMITTER: Fan QW
PROVIDER: S-EPMC3819146 | biostudies-literature | 2013 Oct
REPOSITORIES: biostudies-literature
Cancer cell 20131001 4
EGFRvIII, a frequently occurring mutation in primary glioblastoma, results in a protein product that cannot bind ligand, but signals constitutively. Deducing how EGFRvIII causes transformation has been difficult because of autocrine and paracrine loops triggered by EGFRvIII alone or in heterodimers with wild-type EGFR. Here, we document coexpression of EGFR and EGFRvIII in primary human glioblastoma that drives transformation and tumorigenesis in a cell-intrinsic manner. We demonstrate enhanceme ...[more]