COMT, neuropsychological function and brain structure in schizophrenia: a systematic review and neurobiological interpretation.

ABSTRACT:

Background

Endophenotypes in genetic psychiatry may increase our understanding of the molecular mechanisms underlying disease risk and its manifestations. We sought to investigate the link between neuropsychological impairments and brain structural abnormalities associated with the COMT Val(158)Met polymorphism in patients with schizophrenia to improve understanding of the pathophysiology of this disorder.

Methods

We performed a systematic review using studies identified in PubMed and MEDLINE (from the date of the first available article to July 2012). Our review examined evidence of an association between the COMT Val(158)Met polymorphism and both neuropsychological performance and brain structure in patients with psychosis, in their relatives and in healthy individuals (st

SUBMITTER: Ira E 

PROVIDER: S-EPMC3819150 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature