Soy food supplementation, dietary fat reduction and peripheral blood gene expression in postmenopausal women--a randomized, controlled trial.

ABSTRACT:

Scope

The effect of soy food supplementation or dietary fat reduction on gene expression is not well studied.

Methods and results

We evaluated the potential of gene expression profiling in peripheral blood mononuclear cells (PBMCs) collected at baseline and at the completion of an 8-wk controlled dietary intervention. Healthy postmenopausal women were randomized to a very-low-fat diet (VLFD; 11% of energy as fat) (n=21), a Step 1 diet (25% energy as fat) supplemented with soy food (SFD; 50 mg isoflavones per day) (n=20), or a control Step 1 diet (CD; 27% energy as fat) with no SFD (n=18). All diets were prepared at the General Clinical Research Center of the University of Southern California. We did not observe any gene that showed variable response across the three dietary

SUBMITTER: Wang J 

PROVIDER: S-EPMC3819223 | biostudies-literature | 2011 Sep

REPOSITORIES: biostudies-literature