A genome-wide association study points out the causal implication of SOX9 in the sex-reversal phenotype in XX pigs.

ABSTRACT: Among farm animals, pigs are known to show XX sex-reversal. In such cases the individuals are genetically female but exhibit a hermaphroditism, or a male phenotype. While the frequency of this congenital disease is quite low (less than 1%), the economic losses are significant for pig breeders. These losses result from sterility, urogenital infections and the carcasses being downgraded because of the risk of boar taint. It has been clearly demonstrated that the SRY gene is not involved in most cases of sex-reversal in pigs, and that autosomal recessive mutations remain to be discovered. A whole-genome scan analysis was performed in the French Large-White population to identify candidate genes: 38 families comprising the two non-affected parents and 1 to 11 sex-reversed full-sib piglets were

SUBMITTER: Rousseau S 

PROVIDER: S-EPMC3819277 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature