A cranial window imaging method for monitoring vascular growth around chronically implanted micro-ECoG devices.

ABSTRACT: Implantable neural micro-electrode arrays have the potential to restore lost sensory or motor function to many different areas of the body. However, the invasiveness of these implants often results in scar tissue formation, which can have detrimental effects on recorded signal quality and longevity. Traditional histological techniques can be employed to study the tissue reaction to implanted micro-electrode arrays, but these techniques require removal of the brain from the skull, often causing damage to the meninges and cortical surface. This is especially unfavorable when studying the tissue response to electrode arrays such as the micro-electrocorticography (micro-ECoG) device, which sits on the surface of the cerebral cortex. In order to better understand the biological changes occurrin

SUBMITTER: Schendel AA 

PROVIDER: S-EPMC3819462 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature