Overexpression of miR-196b and HOXA10 characterize a poor-prognosis gastric cancer subtype.

ABSTRACT:

Aim

To identify molecular biologic differences between two gastric adenocarcinoma subgroups presenting different prognoses through the analysis of microRNA and protein expression.

Methods

Array technologies were used to generate 1146 microRNAs and 124 proteins expression profiles of samples from 60 patients with gastric cancer. For the integrative analysis, we used established mRNA expression data published in our previous study. Whole mRNA expression levels were acquired from microarray data for 60 identical gastric cancer patients. Two gastric adenocarcinoma subgroups with distinct mRNA expression profiles presented distinctly different prognoses. MicroRNA and protein expression patterns were compared between gastric cancer tissue and normal gastric tissue and between two

SUBMITTER: Lim JY 

PROVIDER: S-EPMC3819543 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature