Human autopsy study of drug-eluting stents restenosis: histomorphological predictors and neointimal characteristics.

ABSTRACT:

Aims

Restenosis in drug-eluting stents (DESs) occurs infrequently, however, it remains a pervasive clinical problem. We interrogated our autopsy registry to determine the underlying mechanisms of DES restenosis, and further we investigated the neointimal characteristics of DESs and compared with bare metal stents (BMSs).

Methods and results

Coronary lesions from patients with DES implants (n = 82) were categorized into four groups based on cross-sectional area narrowing: patent (<50%), intermediate (50-74%), restenotic (≥ 75% with residual lumen), and total occlusion (organized thrombus within the stent). Restenosis and occlusion were significantly dependent on the total stented length: restenosis (26.7 mm) and occlusion (25.7 mm) compared with patent DESs (17.3 mm). Further

SUBMITTER: Nakano M 

PROVIDER: S-EPMC3819590 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature