Extracts from Acacia catechu suppress HIV-1 replication by inhibiting the activities of the viral protease and Tat.

ABSTRACT:

Background

Acacia catechu (Mimosa family) stem bark extracts have been used traditionally as a dietary supplement as well as a folk medicine given its reported anti-inflammatory, immunomodulatory, hepatoprotective, antioxidant, anti-microbial and anti-tumor activities. The present study was undertaken to evaluate the anti-HIV-1 activity of the extracts from stem bark of A. catechu.

Methods

The aqueous and 50% ethanolic extracts of A. catechu stem bark were prepared and 50% ethanolic extract was further fractioned by successively partitioning with petroleum ether, chloroform and n-butanol. All the extracts and fractions were evaluated for cytotoxicity and anti-HIV-1 activity using different in vitro assays. The active n-butanol fraction was evaluated for its inhibition agains

SUBMITTER: Nutan 

PROVIDER: S-EPMC3819669 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature