SORBS2 and TLR3 induce premature senescence in primary human fibroblasts and keratinocytes.

ABSTRACT:

Background

Genetic aberrations are required for the progression of HPV-induced cervical precancers. A prerequisite for clonal expansion of cancer cells is unlimited proliferative capacity. In a cell culture model for cervical carcinogenesis loss of genes located on chromosome 4q35→qter and chromosome 10p14-p15 were found to be associated with escape from senescence. Moreover, by LOH and I-FISH analyses a higher frequency of allele loss of these regions was also observed in cervical carcinomas as compared to CIN3. The aim of this study was to identify candidate senescence-related genes located on chromosome 4q35→qter and chromosome 10p14-p15 which may contribute to clonal expansion at the transition of CIN3 to cancer.

Methods

Microarray expression analyses were used to identi

SUBMITTER: Liesenfeld M 

PROVIDER: S-EPMC3819711 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature