An acute change in lung allocation score and survival after lung transplantation: a cohort study.

ABSTRACT:

Background

Lung transplantation is an effective treatment for patients with advanced lung disease. In the United States, lungs are allocated on the basis of the lung allocation score (LAS), a composite measure of transplantation urgency and utility. Clinical deteriorations result in increases to the LAS; however, whether the trajectory of the LAS has prognostic significance is uncertain.

Objective

To determine whether an acute increase in the LAS before lung transplantation is associated with reduced posttransplant survival.

Design

Retrospective cohort study of adult lung transplant recipients listed for at least 30 days between 4 May 2005 (LAS implementation) and 31 December 2010 in the United Network for Organ Sharing registry. An acute increase in the LAS was defin

SUBMITTER: Tsuang WM 

PROVIDER: S-EPMC3819715 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature