Inflammatory responses in primary muscle cell cultures in Atlantic salmon (Salmo salar).

ABSTRACT:

Background

The relationship between fish health and muscle growth is critical for continued expansion of the aquaculture industry. The effect of immune stimulation on the expression of genes related to the energy balance of fish is poorly understood. In mammals immune stimulation results in major transcriptional changes in muscle, potentially to allow a reallocation of amino acids for use in the immune response and energy homeostasis. The aim of this study was to investigate the effects of immune stimulation on fish muscle gene expression.

Results

Atlantic salmon (Salmo salar) primary muscle cell cultures were stimulated with recombinant (r)IL-1β, a major proinflammatory cytokine, for 24 h in order to simulate an acute immune response. The transcriptomic response was determi

SUBMITTER: Pooley NJ 

PROVIDER: S-EPMC3819742 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature