Caffeine for the prevention of postoperative nausea and vomiting.

ABSTRACT:

Context

Postoperative nausea and vomiting (PONV) is common after ambulatory surgery performed under general anesthesia. Anecdotal evidence suggests that caffeine may be useful in preventing PONV.

Aims

The aim of the study was to determine efficacy of intravenous (IV) caffeine given prior to surgery is effective prophylaxis against PONV.

Settings and design

We conducted a prospective, randomized, double-blind, placebo-controlled study.

Subject and methods

Patients at moderate or high risk of PONV were randomized to receive IV caffeine (500 mg) or saline placebo during general anesthesia; all patients received dexamethasone and dolasetron.

Statistical analysis

Statistical comparisons were tested using bivariable linear and logistic regression for each outc

SUBMITTER: Steinbrook RA 

PROVIDER: S-EPMC3819849 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature