Developmental programming of growth: genetic variant in GH2 gene encoding placental growth hormone contributes to adult height determination.

ABSTRACT:

Introduction

Given the physiological role of placental growth hormone (PGH) during intrauterine development and growth, genetic variation in the coding Growth hormone 2 (GH2) gene may modulate developmental programming of adult stature. Two major GH2 variants were described worldwide, determined by single polymorphism (rs2006123; c.171 + 50C > A). We sought to study whether GH2 variants may contribute to adult anthropometric measurements.

Methods

Genotyping of GH2 SNP rs2006123 by RFLP, testing its genetic association with adult height and Body Mass Index (BMI) by linear regression analysis, and combining the results of three individual study samples in meta-analysis.

Study samples

HYPEST (Estonia), n = 1464 (506 men/958 women), CADCZ (Czech), n = 871 (518/353); UFA (

SUBMITTER: Timasheva Y 

PROVIDER: S-EPMC3820034 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature