The importance of dose, frequency and duration of vitamin D supplementation for plasma 25-hydroxyvitamin D.

ABSTRACT: The importance of dose, frequency and duration of vitamin D supplementation for plasma 25(OH)D levels is not well described and rarely reported for supplementation that exceeds 2000 IU per day. The objective is to examine dose, frequency and duration of supplementation in relation to plasma 25(OH)D in a large population-based sample. We accessed data on 2714 volunteers that contributed to 4224 visits and applied multilevel regression. Compared to not using supplements, a minimum regimen of 1000-2000 IU once or twice per week for one month was not effective in raising 25(OH)D. Compared to this minimum regimen, higher doses of 2000-3000, 3000-4000, and 5000 IU or more were associated with a 7.49, 13.19 and 30.22 nmol/L 25(OH)D increase, respectively; frequencies of three to four, five to six

SUBMITTER: Chao YS 

PROVIDER: S-EPMC3820059 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature