Grading amino acid properties increased accuracies of single point mutation on protein stability prediction.

ABSTRACT:

Background

Protein stabilities can be affected sometimes by point mutations introduced to the protein. Current sequence-information-based protein stability prediction encoding schemes of machine learning approaches include sparse encoding and amino acid property encoding. Property encoding schemes employ physical-chemical information of the mutated protein environments, however, they produce complexity in the mean time when many properties joined in the scheme. The complexity introduces noises that affect machine learning algorithm accuracies. In order to overcome the problem we described a new encoding scheme that graded twenty amino acids into groups according to their specific property values.

Results

We employed three predefined values, 0.1, 0.5, and 0.9 to represent 'we

SUBMITTER: Liu J 

PROVIDER: S-EPMC3820156 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature