A new family of predicted Kruppel-like factor genes and pseudogenes in placental mammals.

ABSTRACT: Krüppel-like factors (KLF) and specificity proteins (SP) constitute a family of zinc-finger-containing transcription factors that play important roles in a wide range of processes including differentiation and development of various tissues. The human genome possesses 17 KLF genes (KLF1-KLF17) and nine SP genes (SP1-SP9) with diverse functions. We used sequence similarity searches and gene synteny analysis to identify a new putative KLF gene/pseudogene named KLF18 that is present in most of the placental mammals with sequenced genomes. KLF18 is a chromosomal neighbor of the KLF17 gene and is likely a product of its duplication. Phylogenetic analyses revealed that mammalian predicted KLF18 proteins and KLF17 proteins experienced elevated rates of evolution and are grouped with KLF1/KLF2/KLF

SUBMITTER: Pei J 

PROVIDER: S-EPMC3820594 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature