The complex interplay of genetic and lifestyle risk factors in type 2 diabetes: an overview.

ABSTRACT: Type 2 diabetes (T2D) is one of the scourges of modern times, with many millions of people affected by the disease. Diabetes occurs most frequently in those who are overweight or obese. However, not all overweight and obese persons develop diabetes, and there are those who develop the disease who are lean and physically active. Certain ethnicities, especially indigenous populations, are at considerably higher risk of obesity and diabetes than those of white European ancestry. The patterns and distributions of diabetes have led some to speculate that the disease is caused by interactions between genetic and obesogenic lifestyle factors. Whilst to many this is a plausible explanation, remarkably little reliable evidence exists to support it. In this review, an overview of published literatur

SUBMITTER: Franks PW 

PROVIDER: S-EPMC3820646 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature