The improbable transmission of Trypanosoma cruzi to human: the missing link in the dynamics and control of Chagas disease.

ABSTRACT: Chagas disease has a major impact on human health in Latin America and is becoming of global concern due to international migrations. Trypanosoma cruzi, the etiological agent of the disease, is one of the rare human parasites transmitted by the feces of its vector, as it is unable to reach the salivary gland of the insect. This stercorarian transmission is notoriously poorly understood, despite its crucial role in the ecology and evolution of the pathogen and the disease. The objective of this study was to quantify the probability of T. cruzi vectorial transmission to humans, and to use such an estimate to predict human prevalence from entomological data. We developed several models of T. cruzi transmission to estimate the probability of transmission from vector to host. Using datasets fro

SUBMITTER: Nouvellet P 

PROVIDER: S-EPMC3820721 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature