Effects of hydroxychloroquine on immune activation and disease progression among HIV-infected patients not receiving antiretroviral therapy: a randomized controlled trial.

ABSTRACT:

Context

Therapies to decrease immune activation might be of benefit in slowing HIV disease progression.

Objective

To determine whether hydroxychloroquine decreases immune activation and slows CD4 cell decline.

Design, setting, and patients

Randomized, double-blind, placebo-controlled trial performed at 10 HIV outpatient clinics in the United Kingdom between June 2008 and February 2011. The 83 patients enrolled had asymptomatic HIV infection, were not taking antiretroviral therapy, and had CD4 cell counts greater than 400 cells/μL.

Intervention

Hydroxychloroquine, 400 mg, or matching placebo once daily for 48 weeks.

Main outcome measures

The primary outcome measure was change in the proportion of activated CD8 cells (measured by the expression of CD38 and

SUBMITTER: Paton NI 

PROVIDER: S-EPMC3821003 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature