Trastuzumab-related cardiotoxicity among older patients with breast cancer.

ABSTRACT:

Purpose

The use of trastuzumab in the adjuvant setting improves outcomes but is associated with cardiotoxicity manifested as congestive heart failure (CHF). The rates and risk factors associated with trastuzumab-related CHF among older patients are unknown.

Patients and methods

Breast cancer patients at least 66 years old with full Medicare coverage, diagnosed with stage I-III breast cancer between 2005 and 2009, and treated with chemotherapy were identified in the SEER-Medicare and in the Texas Cancer Registry-Medicare databases. The rates and risk factors associated with CHF were evaluated. Chemotherapy, trastuzumab use, comorbidities, and CHF were identified using International Classification of Diseases, version 9, and Healthcare Common Procedure Coding System codes. Ana

SUBMITTER: Chavez-MacGregor M 

PROVIDER: S-EPMC3821011 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature