Characterisation of the androgen regulation of glycine N-methyltransferase in prostate cancer cells.

ABSTRACT: The development and growth of prostate cancer is dependent on androgens; thus, the identification of androgen-regulated genes in prostate cancer cells is vital for defining the mechanisms of prostate cancer development and progression and developing new markers and targets for prostate cancer treatment. Glycine N-methyltransferase (GNMT) is a S-adenosylmethionine-dependent methyltransferase that has been recently identified as a novel androgen-regulated gene in prostate cancer cells. Although the importance of this protein in prostate cancer progression has been extensively addressed, little is known about the mechanism of its androgen regulation. Here, we show that GNMT expression is stimulated by androgen in androgen receptor (AR) expressing cells and that the stimulation occurs at the m

SUBMITTER: Ottaviani S 

PROVIDER: S-EPMC3821059 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature