Integrative modelling of the influence of MAPK network on cancer cell fate decision.

ABSTRACT: The Mitogen-Activated Protein Kinase (MAPK) network consists of tightly interconnected signalling pathways involved in diverse cellular processes, such as cell cycle, survival, apoptosis and differentiation. Although several studies reported the involvement of these signalling cascades in cancer deregulations, the precise mechanisms underlying their influence on the balance between cell proliferation and cell death (cell fate decision) in pathological circumstances remain elusive. Based on an extensive analysis of published data, we have built a comprehensive and generic reaction map for the MAPK signalling network, using CellDesigner software. In order to explore the MAPK responses to different stimuli and better understand their contributions to cell fate decision, we have considered the

SUBMITTER: Grieco L 

PROVIDER: S-EPMC3821540 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature