Patterns of subregional mesiotemporal disease progression in temporal lobe epilepsy.

ABSTRACT:

Objective

Evidence for disease progression in the mesiotemporal lobe is mainly derived from global volumetry of the hippocampus. In this study, we tracked progressive structural changes in the hippocampus, amygdala, and entorhinal cortex in drug-resistant temporal lobe epilepsy at a subregional level. Furthermore, we evaluated the relation between disease progression and surgical outcome.

Methods

We combined cross-sectional modeling of disease duration in a large cohort of patients (n = 134) and longitudinal analysis in a subset that delayed surgery (n = 31). To track subregional pathology, we applied surface-shape analysis techniques on manual mesiotemporal labels.

Results

Longitudinal and cross-sectional designs showed consistent patterns of progressive atrophy in h

SUBMITTER: Bernhardt BC 

PROVIDER: S-EPMC3821710 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature