Clinically meaningful performance benchmarks in MS: timed 25-foot walk and the real world.

ABSTRACT:

Objective

Identify and validate clinically meaningful Timed 25-Foot Walk (T25FW) performance benchmarks in individuals living with multiple sclerosis (MS).

Methods

Cross-sectional study of 159 MS patients first identified candidate T25FW benchmarks. To characterize the clinical meaningfulness of T25FW benchmarks, we ascertained their relationships to real-life anchors, functional independence, and physiologic measurements of gait and disease progression. Candidate T25FW benchmarks were then prospectively validated in 95 subjects using 13 measures of ambulation and cognition, patient-reported outcomes, and optical coherence tomography.

Results

T25FW of 6 to 7.99 seconds was associated with a change in occupation due to MS, occupational disability, walking with a cane,

SUBMITTER: Goldman MD 

PROVIDER: S-EPMC3821712 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature