Amyloid-first and neurodegeneration-first profiles characterize incident amyloid PET positivity.

ABSTRACT:

Objective

To estimate the incidence of and to characterize cognitive and imaging findings associated with incident amyloid PET positivity.

Methods

Cognitively normal (CN) participants in the Mayo Clinic Study of Aging who had 2 or more serial imaging assessments, which included amyloid PET, FDG-PET, and MRI at each time point, were eligible for analysis (n = 207). Twelve subjects with Alzheimer disease dementia were included for comparison.

Results

Of the 123 CN participants who were amyloid-negative at baseline, 26 met criteria for incident amyloid PET positivity. Compared to the 69 subjects who remained stable amyloid-negative, on average these 26 did not differ on any imaging, demographic, or cognitive variables except amyloid PET (by definition) and task-free func

SUBMITTER: Jack CR 

PROVIDER: S-EPMC3821718 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature